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Wegovy side effects, plainly

Most people get some GI upset, especially while titrating up. Here's the full list — common and serious — plus the boxed warning worth actually reading.

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THE SHORT VERSION

Most side effects are GI — nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, indigestion. Worst right after a dose increase, easing at a stable dose.

Per Wegovy (semaglutide) prescribing information, Novo Nordisk. Not medical advice — call your prescriber about any symptom that worries you.

SEC. 02

Common side effects

C—01

Nausea & GI upset

The most reported side effect. Slowed stomach emptying is the mechanism, not a sign anything's wrong.

C—02

Diarrhea or constipation

Either direction is common, especially early on and after a dose increase.

C—03

Vomiting & indigestion

Less common than nausea but listed. Persistent vomiting is a reason to call your prescriber.

C—04

Stomach pain

Mild abdominal discomfort is common; severe pain that won't go away is not — see below.

C—05

Headache & fatigue

Reported by a meaningful share of patients in trials, usually mild.

C—06

Injection site reaction

Redness or soreness where you inject. Rotating sites reduces this.

SEC. 03

Serious — call your doctor

Symptom
Possible cause
Severe stomach pain that won't go away, may spread to your back
Pancreatitis
Upper stomach pain, fever, yellowing skin or eyes, clay-colored stools
Gallbladder problem
Dizziness, sweating, confusion, shakiness, fast heartbeat
Low blood sugar (higher risk with insulin or a sulfonylurea)
Swelling of face, lips, tongue; trouble breathing; severe rash
Allergic reaction
Decreased urination, swelling in legs or feet, unusual tiredness
Kidney problems (often from dehydration)
Sudden vision changes — especially if you have diabetic retinopathy
Diabetic retinopathy complications
Neck lump, hoarseness, trouble swallowing, shortness of breath
Thyroid tumor warning (boxed warning)

Wegovy carries a boxed warning: semaglutide caused thyroid C-cell tumors in rodent studies, and it's not known if this occurs in people. Do not use Wegovy if you or a family member has had medullary thyroid carcinoma (MTC) or have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). This list is not exhaustive — read the full prescribing information and ask your prescriber about anything unclear.

SEC. 04

How the app helps

F—01

Log symptoms

Tag nausea, headaches, or anything else against the exact dose and day it happened.

F—02

Spot the pattern

See whether symptoms cluster around dose increases — useful context for your next appointment.

F—03

Export for your doctor

A clean timeline of dose, site, and symptoms — ready to share, no digging through notes.

F—04

Get reminded

Never lose track of which dose you're on — the app carries your titration schedule automatically.

F—05

Rotate the site

Cuts down on injection-site soreness by suggesting where to go next.

F—06

Shot history

Every injection, dose and note on one synced timeline across devices.

SEC. 05

Q & A

How long do Wegovy side effects last?Q—01 +
The most common side effects, like nausea and diarrhea, usually ease within a few weeks as your body adjusts to a given dose. They can flare again after each increase.
Does Wegovy cause hair loss?Q—02 +
Hair loss wasn't a commonly reported side effect in Wegovy's clinical trials. When it happens, it's usually linked to rapid weight loss itself rather than a direct drug effect, and typically improves over time.
Is nausea worse with Wegovy or Zepbound?Q—03 +
In the head-to-head SURMOUNT-5 trial, nausea was reported by about 24% of Wegovy patients versus about 44% of Zepbound patients; vomiting was about 12% versus 24%.
What is Wegovy's boxed warning about?Q—04 +
Semaglutide caused thyroid C-cell tumors in rodent studies; it's not known if this happens in people. Wegovy shouldn't be used by anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.
When should I call my doctor?Q—05 +
Severe abdominal pain that won't go away, signs of a gallbladder problem, any allergic reaction symptoms, a neck lump or hoarseness, sudden vision changes, or signs of dehydration or kidney trouble.

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