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Who shouldn't take Mounjaro

Every drug label has a "do not use if" list. Mounjaro's is short but specific — here's exactly who it rules out, and what to flag to your prescriber.

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THE HARD STOPS

Do not take Mounjaro if you or a family member has had medullary thyroid carcinoma (MTC), if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you've had a serious allergic reaction to tirzepatide or any Mounjaro ingredient.

Per FDA prescribing information for Mounjaro (tirzepatide), Eli Lilly. Not medical advice — this list is not exhaustive; review your full history with your prescriber.

SEC. 02

Absolute contraindications

Condition
Why it matters
Personal or family history of medullary thyroid carcinoma (MTC)
BOXED WARNING — DO NOT USE
Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
BOXED WARNING — DO NOT USE
Prior serious allergic reaction to tirzepatide or Mounjaro ingredients
DO NOT USE
Type 1 diabetes
NOT APPROVED FOR THIS USE

Mounjaro's boxed warning exists because tirzepatide caused thyroid C-cell tumors in rodent studies; whether this occurs in humans is unknown. That uncertainty is exactly why the MTC/MEN 2 exclusions are absolute, not a judgment call.

SEC. 03

Discuss with your prescriber

Situation
Why it matters
History of pancreatitis
NOT KNOWN IF SAFE — DISCUSS FIRST
Severe stomach problems (e.g. gastroparesis)
MAY WORSEN GI SYMPTOMS
Kidney problems
GI SIDE EFFECTS CAN WORSEN DEHYDRATION RISK
Diabetic retinopathy history
MONITOR FOR VISION CHANGES
Taking insulin or a sulfonylurea
HIGHER RISK OF LOW BLOOD SUGAR
Pregnant, planning to be, or breastfeeding
NOT KNOWN IF SAFE — DISCUSS FIRST
Taking oral birth control
MAY BE LESS EFFECTIVE FOR 4 WEEKS AFTER START/DOSE INCREASE
SEC. 04

How the app helps

F—01

Log every symptom

Track anything unusual against the exact dose and day — useful context if you need to flag something to your prescriber.

F—02

Never miss a check-in

Set reminders around follow-up appointments where these precautions are worth revisiting as your dose changes.

F—03

Export for your doctor

A clean history of dose, timing, and notes — ready to share, no digging through old messages.

SEC. 05

Q & A

What are the cons of taking Mounjaro?Q—01 +
GI side effects (nausea, diarrhea, vomiting, constipation) are common, especially during dose increases. It carries a boxed warning on thyroid tumors, requires a weekly injection, and can be costly without insurance or a savings card.
What should you not take with Mounjaro?Q—02 +
Tell your prescriber about any insulin or sulfonylureas (risk of low blood sugar), oral birth control (may be less effective for 4 weeks after starting or each dose increase), and any other GLP-1 or GIP receptor agonist medicines.
Why should I not take Mounjaro?Q—03 +
You should not take Mounjaro if you or a family member has had medullary thyroid carcinoma (MTC), if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you've had a serious allergic reaction to tirzepatide or any Mounjaro ingredient.
What organ can Mounjaro affect?Q—04 +
The prescribing information highlights the thyroid (boxed warning), pancreas (pancreatitis risk), gallbladder, and kidneys (risk from dehydration due to GI side effects). Report any related symptoms to your prescriber promptly.
What should I avoid while taking Mounjaro?Q—05 +
Avoid skipping meals in ways that increase low-blood-sugar risk if you're also on insulin or a sulfonylurea, avoid relying on oral birth control alone for the first 4 weeks after starting or increasing dose, and avoid ignoring severe or persistent abdominal pain.

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